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. 2007 Sep;45(3):239-43.
doi: 10.3347/kjp.2007.45.3.239.

Validity of MAST-CLA for diagnosis of arthropod allergy using receiver operating characteristic (ROC) analysis

Joon-Soo Park  1 , Hae-Seon Nam, Yong-Bae Kim, Young-Jin Choi, Sang-Han Lee, Sung-Ho Kim
Affiliations

Validity of MAST-CLA for diagnosis of arthropod allergy using receiver operating characteristic (ROC) analysis

Joon-Soo Park et al. Korean J Parasitol. 2007 Sep.

Abstract

Many allergists are currently focusing on the development of new diagnostic tools, and are attempting to improve both the sensitivity and specificity. A multiple allergen simultaneous test-chemiluminescent assay (MASTCLA) is one of the most popular diagnostic tools used in the Republic of Korea. However, there remains controversy among allergists with regard to the cut-off point for a positive result. The present study was conducted in order to determine the validity of MAST-CLA as compared with that of the skin prick test, with particular emphasis on arthropod allergens, on the basis of percentage agreement rates and kappa-values, and also to suggest the optimal positive cutoff points using receiver operating characteristic (ROC) curves. The study was conducted with 97 subjects (54 men, 43 women). Optimal individual cut-off points were calculated as follows; class II for Dermatophagoides farinae, class I for Dermatophagoides pteronyssinus, and trace for a cockroach mix. These findings suggest that attempting to apply optimal individual cut-off points will be a good way of improving diagnostic tests, particularly MAST-CLA.

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Figures

Fig. 1
Fig. 1
ROC curves of MAST-CLA by different cut-off points compare to skin prick test about arthropod allergens. *: optimal cut-off point.
See this image and copyright information in PMC

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