Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Sep;45(3):239-43.
doi: 10.3347/kjp.2007.45.3.239.

Validity of MAST-CLA for diagnosis of arthropod allergy using receiver operating characteristic (ROC) analysis

Joon-Soo Park  1 , Hae-Seon Nam, Yong-Bae Kim, Young-Jin Choi, Sang-Han Lee, Sung-Ho Kim
Affiliations

Validity of MAST-CLA for diagnosis of arthropod allergy using receiver operating characteristic (ROC) analysis

Joon-Soo Park et al. Korean J Parasitol. 2007 Sep.

Abstract

Many allergists are currently focusing on the development of new diagnostic tools, and are attempting to improve both the sensitivity and specificity. A multiple allergen simultaneous test-chemiluminescent assay (MASTCLA) is one of the most popular diagnostic tools used in the Republic of Korea. However, there remains controversy among allergists with regard to the cut-off point for a positive result. The present study was conducted in order to determine the validity of MAST-CLA as compared with that of the skin prick test, with particular emphasis on arthropod allergens, on the basis of percentage agreement rates and kappa-values, and also to suggest the optimal positive cutoff points using receiver operating characteristic (ROC) curves. The study was conducted with 97 subjects (54 men, 43 women). Optimal individual cut-off points were calculated as follows; class II for Dermatophagoides farinae, class I for Dermatophagoides pteronyssinus, and trace for a cockroach mix. These findings suggest that attempting to apply optimal individual cut-off points will be a good way of improving diagnostic tests, particularly MAST-CLA.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
ROC curves of MAST-CLA by different cut-off points compare to skin prick test about arthropod allergens. *: optimal cut-off point.
See this image and copyright information in PMC

References

    1. Agata H, Yomo A, Hanashiro Y, Muraki T, Kondo N, Orii T. Comparison of the MAST chemiluminescent assay system with RAST and skin tests in allergic children. Ann Allergy. 1993;70:153–157. - PubMed
    1. Brown CR, Higgins KW, Frazer K, Schoelz LK, Dyminski JW, Marinkovich VA, Miller SP, Burd JF. Simultaneous determination of total IgE and allergen-specific IgE in serum by the MAST chemiluminescent assay system. Clin Chem. 1985;31:1500–1505. - PubMed
    1. Finnery JP, Summerell S, Holgate ST. Relationship between skin-prick tests, the multiple allergosorbent test and symptoms of allergic disease. Clin Exp Allergy. 1989;19:51–56. - PubMed
    1. Hwang KY, Park JS, Ahn HC, Nam HS. Prevalence of arthropod antibodies in Korean patients with allergic rhinitis. Korean J Parasitol. 2001;39:197–199. - PMC - PubMed
    1. Illi S, von Mutius E, Lau S, Nickel R, Niggeman B, Sommerfeld C, Wahn U. The pattern of atopic sensitization is associated with the development of asthma in childhood. J Allergy Clin Immunol. 2001;108:709–714. - PubMed

Publication types