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Comment
. 2007 Nov;152(6):835-7.
doi: 10.1038/sj.bjp.0707463. Epub 2007 Sep 17.

Is there a functional correlate of Kv1.5 in the ventricle of canine heart and what would it mean for the use of I(Kur) blockers?

E Wettwer  1
Affiliations
Comment

Is there a functional correlate of Kv1.5 in the ventricle of canine heart and what would it mean for the use of I(Kur) blockers?

E Wettwer. Br J Pharmacol. 2007 Nov.

Abstract

The cardiac ultrarapid outward current I(Kur), encoded by KCNA5, is of special pharmacological interest, because it is considered to be atrium-specific. I(Kur) has therefore become a target in the therapy of atrial tachyarrhythmias. However, the concept of atrium specificity is only valid if a functional I(Kur) current is in fact absent from the ventricle. However, new work has detected a I(Kur)-like current in canine ventricular myocytes, sensitive to 4-aminopyridine and suppressed by the I(Kur) blocker DPO-1, findings that support the existence of a functional ventricular I(Kur). These indications are, however, indirect and more effort is needed to clarify unequivocally the putative role of an expectedly small I(Kur) component in the ventricle.

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References

    1. Amos GJ, Wettwer E, Metzger F, Li Q, Himmel HM, Ravens U. Differences between outward currents of human atrial and subepicardial ventricular myocytes. J Physiol. 1996;491:31–50. - PMC - PubMed
    1. Blaauw Y, Gögelein H, Tieleman RG, Van Hunnik A, Schotten U, Allessie MA. ‘Early' class III drugs for the treatment of atrial fibrillation. Efficacy and atrial selectivity of AVE0118 in remodelled atria of the goat. Circulation. 2004;110:1717–1724. - PubMed
    1. Ehrlich JR, Nattel S, Hohnloser SH. Novel anti-arrhythmic drugs for atrial fibrillation management. Curr Vasc Pharmacol. 2007;5:185–195. - PubMed
    1. Fedida D, Eldstrom J, Hesketh JC, Lamorgese M, Castel L, Steele DF, et al. Kv1.5 is an important component of repolarizing K+ current in canine atrial myocytes. Circ Res. 2003;93:744–751. - PubMed
    1. Feng J, Wible B, Li GR, Wang Z, Nattel S. Antisense oligonucleotides directed aginst Kv1-5 mRNA specifically inhibit ultrarapid delayed rectifier K+ current in cultured adult human atrial myocytes. Circ Res. 1997;80:572–579. - PubMed

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