Elimination of Candida albicans from kidneys of mice during short-term systemic infections

Abstract

The candidacidal activity of kidneys, liver, and spleen's phagocytic systems was studied in mouse. Different strains of mice were inoculated intravenously (i.v.) with 1 to 2.6 x 10(4) viable Candida albicans. Elimination of the microorganisms from the kidneys, liver, and spleen were evaluated by enumeration of colony forming units (C.F.U.) recovered from homogenates of organs dissected within a short period of time (0 to 5 hr). The results indicated that the kidneys possess a capable phagocytic system which was able to eliminate the microorganisms as efficiently as those of liver and spleen. Furthermore, the ability of the liver and spleen phagocytic system as well as that of kidneys were significantly enhanced when animals were treated with Bacillus Calmette-Guerin (BCG) of mycobacterium bovis four weeks prior to induction of systemic infection with C. albicans.