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. 2007 Sep 18:7:108.
doi: 10.1186/1471-2334-7-108.

Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis

Kristine Marie Jessen  1 , Sarah Bjerre Lindboe, Anncatrine Luisa Petersen, Jesper Eugen-Olsen, Thomas Benfield
Affiliations

Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis

Kristine Marie Jessen et al. BMC Infect Dis. .

Abstract

Background: Several studies have investigated single nucleotide polymorphisms (SNPs) in candidate genes associated with sepsis and septic shock with conflicting results. Only few studies have combined the analysis of multiple SNPs in the same population.

Methods: Clinical data and DNA from consecutive adult patients with culture proven Gram negative bacteremia admitted to a Danish hospital between 2000 and 2002. Analysis for commonly described SNPs of tumor necrosis-alpha, (TNF-alpha), interleukin-1 beta (IL-1 beta), plasminogen activator-1 (PAI-1), urokinase plasminogen activator (uPA), CD14 and toll-like receptor 4 (TLR4) was done.

Results: Of 319 adults, 74% had sepsis, 19% had severe sepsis and 7% were in septic shock. No correlation between severity or outcome of sepsis was observed for the analyzed SNPs of TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 or TLR-4. In multivariate Cox proportional hazard regression analysis, increasing age, polymicrobial infection and haemoglobin levels were associated with in-hospital mortality.

Conclusion: We did not find any association between TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms and outcome of Gram negative sepsis. Other host factors appear to be more important than the genotypes studied here in determining the severity and outcome of Gram negative sepsis.

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Figures

Figure 1
Figure 1
90-day survival from Gram negative sepsis according to disease severity. Log-rank test: P = 0.014.
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References

    1. Martin GS, Mannino GM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. 2003;348:1546–1554. - PubMed
    1. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101:1644–1655. - PubMed
    1. Russell JA. Management of sepsis. N Engl J Med. 2006;355:1699–1713. doi: 10.1056/NEJMra043632. - DOI - PubMed
    1. Esmon CT. Interactions between the innate immune and blood coagulation systems. Trends Immunol. 2004;25:536–542. doi: 10.1016/j.it.2004.08.003. - DOI - PMC - PubMed
    1. Beutler B, Hoebe K, Du X, Ulevitch RJ. How we detect microbes and respond to them: the Toll-like receptors and their transducers. J Leukoc Biol. 2003;74:479–485. doi: 10.1189/jlb.0203082. - DOI - PubMed

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