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Review
. 2007 Aug;9(2):97-103.
doi: 10.1007/s11883-007-0004-9.

The role of lipoprotein-associated phospholipase A2 as a marker for atherosclerosis

Salim S Virani  1 , Vijay Nambi
Affiliations
Review

The role of lipoprotein-associated phospholipase A2 as a marker for atherosclerosis

Salim S Virani et al. Curr Atheroscler Rep. 2007 Aug.

Abstract

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that belongs to the superfamily of phospholipase A2 enzymes. Although initial studies showed that Lp-PLA2 might be protective against atherosclerosis, emerging data seem to suggest that Lp-PLA2 may be proatherogenic, which is an effect thought to be mediated by lysophosphatidylcholine and oxidized nonesterified fatty acids, two mediators generated by Lp-PLA2. This article reviews the potential mechanisms by which Lp-PLA2 may participate in the pathogenesis of atherosclerosis and its clinical manifestations, namely, coronary artery disease and stroke.

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