Review
doi: 10.1111/1523-1747.ep12482134.
Factors regulating growth and pigmentation of melanoma cells
- PMID: 178804
- DOI: 10.1111/1523-1747.ep12482134
Item in Clipboard
Review
Factors regulating growth and pigmentation of melanoma cells
J Invest Dermatol.
1976 Apr.
Free article
Abstract
Growth and melanization are intimately related in melanoma cells. MSH, by promoting elevated cyclic AMP levels, causes increases in melanization, cessation of growth, and gross morphologic changes in Cloudman S-91 melanoma cells. Growth inhibition results from high levels of cyclic AMP while growth stimulation occurs with lower levels. During melanization, oxidation products of tyrosine are generated which are toxic to the cells. Genetic studies have revealed that some of these processes are related through common biochemical pathways. This article reviews work of recent years on such regulatory mechanisms in melanoma.
Similar articles
-
Melanoma cells resistant to inhibition of growth by melanocyte stimulating hormone.Proc Natl Acad Sci U S A. 1975 Mar;72(3):951-5. doi: 10.1073/pnas.72.3.951. Proc Natl Acad Sci U S A. 1975. PMID: 165495 Free PMC article.
-
Molecular biology of pigment cells. Molecular controls in mammalian pigmentation.Yale J Biol Med. 1973 Dec;46(5):430-43. Yale J Biol Med. 1973. PMID: 4360458 Free PMC article. No abstract available.
-
MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cyclic AMP levels and tyrosinase activity without inducing melanogenesis.J Cell Sci. 1989 Apr;92 ( Pt 4):551-9. doi: 10.1242/jcs.92.4.551. J Cell Sci. 1989. PMID: 2557357
-
Ultrastructure and cell biology of pigment cells. Intracellular dynamics and the fine structure of melanocytes with special reference to the effects of MSH and cyclic AMP on microtubules and 10-nm filaments.Yale J Biol Med. 1973 Dec;46(5):337-60. Yale J Biol Med. 1973. PMID: 4360457 Free PMC article. Review. No abstract available.
-
The nature and biological effects of factors responsible for proliferation and differentiation of melanocytes.Pigment Cell Res. 1992;Suppl 2:43-7. doi: 10.1111/j.1600-0749.1990.tb00347.x. Pigment Cell Res. 1992. PMID: 1329075 Review. No abstract available.
Cited by
-
Response of melanoma cells to alpha-MSH and cAMP stimulation.J Tongji Med Univ. 1988;8(2):89-93. doi: 10.1007/BF02887801. J Tongji Med Univ. 1988. PMID: 2854857 No abstract available.
-
Cloning and expression of cDNA encoding mouse tyrosinase.Nucleic Acids Res. 1986 Mar 25;14(6):2413-27. doi: 10.1093/nar/14.6.2413. Nucleic Acids Res. 1986. PMID: 3008090 Free PMC article.
-
The killing effect of 4-S-cysteaminylphenol, a newly synthesised melanin precursor, on B16 melanoma cell lines.Br J Cancer. 1991 Feb;63(2):187-90. doi: 10.1038/bjc.1991.46. Br J Cancer. 1991. PMID: 1997095 Free PMC article.
-
Cell type conversion in a mouse melanoma cell clone.In Vitro. 1982 Aug;18(8):661-7. doi: 10.1007/BF02796420. In Vitro. 1982. PMID: 6813245
-
Enhanced melanogenesis of murine melanoma cells cultured on or in collagen gel.Arch Dermatol Res. 1990;282(4):263-6. doi: 10.1007/BF00371647. Arch Dermatol Res. 1990. PMID: 2115320
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
