Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects
- PMID: 17882604
- DOI: 10.1080/10550490701525723
Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects
Abstract
Comorbidity between drug abuse and mental illness is very common, but the association of such comorbidity with specific responses to drugs of abuse remains obscure. The current study examined the relationship between the presence of non-psychotic Axis I psychiatric diagnoses and the frequency and severity of cocaine-induced psychosis. We interviewed 243 unrelated cocaine-dependent adults [37% European American (EA), 52.3% African American (AA); 58.8% male] using the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) to establish DSM-IV diagnoses, and two instruments for the identification of cocaine-induced paranoia, the Cocaine Experience Questionnaire (CEQ) and the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP). Comorbid substance use and psychiatric disorders were common in this cocaine-dependent sample. Ninety percent of subjects met criteria for substance use disorders other than cocaine dependence; common non-substance-use disorders included antisocial personality disorder (ASPD), adult ASPD, major depression, and attention deficit-hyperactivity disorder (ADHD). Comorbid opioid dependence was more common in EA subjects than in AA participants. After correction for multiple comparisons, a lifetime diagnosis of ADHD was associated with the categorical presence of CIP (p = 0.007), as well as significantly more severe CIP symptoms. Comorbid substance use and psychiatric disorders are very common among individuals with cocaine dependence. Comorbid ADHD increases the odds of an individual endorsing CIP, suggesting some common basis for these phenomena.
Comment in
-
Response to "Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects".Am J Addict. 2008 May-Jun;17(3):247-8; author reply 249-50. doi: 10.1080/10550490802019857. Am J Addict. 2008. PMID: 18464004 No abstract available.
Similar articles
-
Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP).Drug Alcohol Depend. 2005 Oct 1;80(1):23-33. doi: 10.1016/j.drugalcdep.2005.03.019. Drug Alcohol Depend. 2005. PMID: 15894433
-
Cocaine-induced psychosis and impulsivity in cocaine-dependent patients.J Addict Dis. 2013;32(3):263-73. doi: 10.1080/10550887.2013.824330. J Addict Dis. 2013. PMID: 24074192
-
Relationship of cocaine and other substance dependence to well-being of high-risk psychiatric patients.Psychiatr Serv. 1998 Jul;49(7):935-40. doi: 10.1176/ps.49.7.935. Psychiatr Serv. 1998. PMID: 9661229
-
An international perspective and review of cocaine-induced psychosis: a call to action.Subst Abus. 2014;35(3):321-7. doi: 10.1080/08897077.2014.933726. Subst Abus. 2014. PMID: 24927026 Review.
-
[Attention-deficit/hyperactivity disorder and substance abuse].Psychiatr Prax. 2003 May;30(4):182-6. doi: 10.1055/s-2003-39496. Psychiatr Prax. 2003. PMID: 12768521 Review. German.
Cited by
-
The stereotypy-inducing and OCD-like effects of chronic 'binge' cocaine are modulated by distinct subtypes of nicotinic acetylcholine receptors.Br J Pharmacol. 2012 Sep;167(2):450-64. doi: 10.1111/j.1476-5381.2012.02023.x. Br J Pharmacol. 2012. PMID: 22568685 Free PMC article.
-
Substance-Induced Psychoses: An Updated Literature Review.Front Psychiatry. 2021 Dec 23;12:694863. doi: 10.3389/fpsyt.2021.694863. eCollection 2021. Front Psychiatry. 2021. PMID: 35002789 Free PMC article. Review.
-
Addiction and cognition.Addict Sci Clin Pract. 2010 Dec;5(2):4-14. Addict Sci Clin Pract. 2010. PMID: 22002448 Free PMC article. Review.
-
A Retrospective Comparative Study in Patients With Cocaine Use Disorder Comorbid With Attention Deficit Hyperactivity Disorder Undergoing an rTMS Protocol Treatment.Front Psychiatry. 2021 Mar 25;12:659527. doi: 10.3389/fpsyt.2021.659527. eCollection 2021. Front Psychiatry. 2021. PMID: 33841218 Free PMC article.
-
Among long-term crack smokers, who avoids and who succumbs to cocaine addiction?Drug Alcohol Depend. 2008 Nov 1;98(1-2):24-9. doi: 10.1016/j.drugalcdep.2008.04.004. Epub 2008 May 21. Drug Alcohol Depend. 2008. PMID: 18499357 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous