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. 2007 Jun;27(3):123-5.

Parathyroid function study in patients submitted to laryngeal surgery for squamous cell carcinoma

M Geminiani  1 , C Aimoni, G Scanelli, A Pastore
Affiliations

Parathyroid function study in patients submitted to laryngeal surgery for squamous cell carcinoma

M Geminiani et al. Acta Otorhinolaryngol Ital. 2007 Jun.

Abstract
in English, Italian

Aim of this study was to investigate any eventual quantitative variations in the serological concentration of parathormone in a homogenous sample of patients suffering from laryngeal squamous cell carcinoma who underwent only surgery. A total of 12 patients (2 female, 10 male), aged between 58 and 76 years, were treated between June 2002 and June 2003. The patients were all affected by T2-T3 laryngeal squamous cell carcinoma. Serum intact parathyroid hormone and calcaemia were measured pre- and post-operatively. Of these patients, 2 underwent total laryngectomy (including thyroid isthmectomy), 5 patients received partial supraglottic laryngectomy, while the remaining 5 were submitted to supracricoid laryngectomy. Results showed a progressive regression of parathyroid hormone level, in only one case and was not, however, below normal limits. Contrary to data reported in the literature, this study indicated that the incidence of hypoparathyroidism following laryngeal surgery, even in radical surgical approaches, proved to be closer to zero.

Questo studio si propone di ricercare variazioni quantitative della concentrazione sierologica di paratormone in un campione omogeneo di pazienti affetti da neoplasia squamocellulare laringea sottoposti a trattamento chirurgico elettivo ed esclusivo. 12 pazienti (2 donne, 10 uomini) di età compresa fra 58 e 76 anni, sono stati trattati dal giugno 2002 al giugno 2003. Tutti i pazienti, affetti da neoplasie squamocellulari maligne in stadio T2 o T3, sono stati sottoposti ad un follow-up comprendente dosaggio sierico di paratormone intatto e calcemia, dopo 3, 6, 12 mesi dall’intervento chirurgico. Di questi pazienti 2 sono stati sottoposti a laringectomia totale (comprendente istmectomia tiroidea), 5 a laringectomia sub-totale sopraglottica e 5 a laringectomia sopracricoidea. In un solo caso si è riscontrata una diminuzione progressiva della paratormonemia, pur non al di sotto dei limiti di norma. A differenza di quanto riportato in letteratura, l’incidenza di ipoparatiroidismo post chirurgia laringea, pur comprendendo approcci chirurgici più o meno demolitivi, è parsa essere prossima allo zero.

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