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. 2007 Nov 15;17(22):6274-9.
doi: 10.1016/j.bmcl.2007.09.012. Epub 2007 Sep 7.

Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

George P Lahm  1 , Thomas M Stevenson, Thomas P Selby, John H Freudenberger, Daniel Cordova, Lindsey Flexner, Cheryl A Bellin, Christine M Dubas, Ben K Smith, Kenneth A Hughes, J Gary Hollingshaus, Christopher E Clark, Eric A Benner
Affiliations

Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

George P Lahm et al. Bioorg Med Chem Lett. .

Abstract

Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented.

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