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Clinical Trial
. 1976 Jun;88(6):931-6.
doi: 10.1016/s0022-3476(76)81044-x.

Evaluation of a live, attenuated respiratory syncytial virus vaccine in infants

P F Wright, T Shinozaki, W Fleet, S H Sell, J Thompson, D T Karzon
Clinical Trial

Evaluation of a live, attenuated respiratory syncytial virus vaccine in infants

P F Wright et al. J Pediatr. 1976 Jun.

Abstract

Respiratory syncytial virus ts-1 is a live attenuated experimental vaccine which was administered intranasally to 25 infants 11 to 19 months of age. Clinical evaluation was carried out following a controlled, double-blind protocol which eliminated observer bias, assessed intercurrent illness, and was designed to detect virus transmission. At the low dose of virus of virus used (100 TCID50) 8 of the 25 recipients were successfully infected with RS virus ts-1 as determined by virus shedding or antibody response.

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