doi: 10.1016/j.phytochem.2007.08.012.
Epub 2007 Sep 20.
Trypanocidal tetrahydrofuran lignans from Peperomia blanda
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- PMID: 17888465
- DOI: 10.1016/j.phytochem.2007.08.012
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Trypanocidal tetrahydrofuran lignans from Peperomia blanda
Phytochemistry.
2008 Jan.
Abstract
Five tetrahydrofuran lignans and two known flavones were isolated from the aerial parts of Peperomia blanda. The structures of the isolated lignans were elucidated by interpretation of their spectroscopic data, including by gHMQC and gHMBC. The relative and absolute configurations of the isolates were determined from NOESY interactions and optical properties, respectively. Four of the lignans were diastereomeric whilst one was of mixed biosynthetic origin. All but one of the lignans exhibited high in vitro trypanocidal activity when assayed against epimastigotes of Trypanosoma cruzi strain Y.
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