Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2007 Aug;41(5):381-91.
doi: 10.1016/j.alcohol.2007.03.011.

Bupropion and nicotine patch as smoking cessation aids in alcoholics

Kathleen M Grant  1 , Stephanie Sinclair Kelley, Lynette M Smith, Sangeeta Agrawal, James R Meyer, Debra J Romberger
Affiliations
Randomized Controlled Trial

Bupropion and nicotine patch as smoking cessation aids in alcoholics

Kathleen M Grant et al. Alcohol. 2007 Aug.

Abstract

This is a double-blind placebo-controlled study of sustained-release bupropion as a smoking cessation aid in alcoholics undergoing treatment for their alcoholism. Participants (N=58) were enrolled within 1 week of entry into alcohol treatment from community and Veterans Affairs Substance Use Disorder programs. All participants received nicotine patch and were invited to attend a smoking cessation lecture and group. Cigarette smoking and alcohol outcomes were measured at 6 months. Bupropion when added to nicotine patch did not improve smoking outcomes. One third of participants on bupropion reported discontinuing the drug during weeks 1-4. Participants reported cigarette outcomes with nicotine patch that are similar to those seen in the general population. All study participants significantly reduced cigarette use. Comorbid affective disorder or antipersonality disorder did not affect outcomes. Alcohol outcomes were improved in those who discontinued cigarettes.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Study Flow Chart. Beck Depression Inventory (BDI), Timeline Follow-back Drinking Calendar (TLFB), Fagerstrom Test for Nicotine Dependence (FTND), Mini-International Neuropsychiatric Interview (MINI).
Fig. 2
Fig. 2
Median number of cigarettes smoked per day at baseline and each follow-up point in bupropion and placebo groups. Each point represents median and error bars are the range of the data.
See this image and copyright information in PMC

References

    1. SAMHSA, editor. Results from the 2004 National Survey On Drug Use and Health: National Findings. United States Department of Health and Human Services; 2005.
    1. Ahluwalia JS, Harris KJ, Catley D, Okuyemi KS, Mayo MS. Sustained-release Bupropion for Smoking Cessation in African Americans: A Randomized Controlled Trial. JAMA. 2002;288:468–474. - PubMed
    1. Aubin HJ, Lebargy F, Berlin I, Bidaut-Mazel C, Chemali-Hudry J, Lagrue G. Efficacy of bupropion and predictors of successful outcome in a sample of French smokers: a randomized placebo-controlled trial. Addiction. 2004;99:1206–1218. - PubMed
    1. Beck AT, Beamesderfer A. Assessment of depression: the depression inventory. Mod. Probl. Pharmacopsychiatry. 1974;7:151–169. - PubMed
    1. Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin S, Bernstein L, Schoenberg JB, Stemhagen A, Fraumeni JF., Jr. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 1988;48:3282–3287. - PubMed

Publication types

MeSH terms