Comment
doi: 10.1016/j.molcel.2007.09.004.
YAP1 meets tumor suppression
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- PMID: 17889659
- DOI: 10.1016/j.molcel.2007.09.004
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Comment
YAP1 meets tumor suppression
Mol Cell.
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Abstract
In this issue of Molecular Cell, Matallanas et al. (2007) demonstrate that RASSF1A-induced apoptosis impinges on the transcriptional coactivator YAP1, whose nuclear translocation and binding to p73 result in proper execution of the cell death pathway. Indeed, RASSF1A silencing in tumors inhibits YAP1-p73-dependent apoptosis.
Comment on
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RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein.Mol Cell. 2007 Sep 21;27(6):962-75. doi: 10.1016/j.molcel.2007.08.008. Mol Cell. 2007. PMID: 17889669 Free PMC article.
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