Unlocking the proteasome door
- PMID: 17889660
- DOI: 10.1016/j.molcel.2007.09.001
Unlocking the proteasome door
Abstract
How proteasomal ATPases stimulate the gate opening of 20S proteasomes is a longstanding question. In the September 7 issue of Molecular Cell, Smith et al. (2007) describe the conserved "HbYX" motif as the key to proteasome gate opening.
Comment on
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Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.Mol Cell. 2007 Sep 7;27(5):731-44. doi: 10.1016/j.molcel.2007.06.033. Mol Cell. 2007. PMID: 17803938 Free PMC article.
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