Nutrient interactions with reference to amino acid and protein metabolism in non-ruminants; particular emphasis on protein-energy relations in man

Abstract

Because the regulation of protein and energy balance is of major research interest in the nutrition and physiology of humans and animals, a selected account of interactions between protein and energy is given here, with particular emphasis on studies in human subjects. The discussion begins with reference to the relations between protein and energy intakes and nitrogen balance; selected aspects of the relations between protein dynamics and energy metabolism among the various mammalian species are then considered. This leads to a brief account of oxidative amino acid catabolism and its relevance to the assessment of amino acid requirements, particularly in adult man. It is concluded that obligatory oxidative losses of amino acids can be used to predict or approximate amino acid requirements in children and adults. The nitrogen-sparing properties of carbohydrate and lipid-derived fuels are then considered. Despite the well-known and profound, yet differential, impacts of dietary protein and energy sources, and their interactions on body protein balance, there remain wide gaps in our understanding of the mechanisms responsible for their effects, such as the quantitative and mechanistic involvement of hormones, including insulin and the counter-regulatory hormones, and the roles played by the major amino acids responsible for the interorgan transport of nitrogen and the regulation of urea production. Additional studies focusing on metabolic nitrogen trafficking would significantly enhance an understanding of how protein and energy interact to achieve the efficient utilization of dietary protein for maintenance and promotion of lean body gain.