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. 1976 May;18(2):776-82.
doi: 10.1128/JVI.18.2.776-782.1976.

Acceleration of transformation of rat embryo cells by rat type C virus

Acceleration of transformation of rat embryo cells by rat type C virus

S Rasheed et al. J Virol. 1976 May.

Abstract

Sprague-Dawley and Fischer rat embryo cells became spontaneously transformed about 20 passages after release of endogenous ecotropic type C virus (SD-RaLV and F-RaLV). The virus-producing transformed cells showed loss of contact inhibition, increased growth rate, and tumorigenicity in vivo. Exogenous infection of other Fischer rat embryo cultures in early passage with SD-RaLV and F-RaLV markedly accelerated their rates of transformation.

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