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Multicenter Study
. 2008 Sep;111(1):139-44.
doi: 10.1007/s10549-007-9752-z. Epub 2007 Sep 21.

The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study

Bernd Frank  1 , Sushila H Rigas, Justo Lorenzo Bermejo, Miriam Wiestler, Kerstin Wagner, Kari Hemminki, Malcolm W Reed, Christian Sutter, Barbara Wappenschmidt, Sabapathy P Balasubramanian, Alfons Meindl, Marion Kiechle, Peter Bugert, Rita K Schmutzler, Claus R Bartram, Christina Justenhoven, Yon-Dschun Ko, Thomas Brüning, Hiltrud Brauch, Ute Hamann, Paul P D Pharoah, Alison M Dunning, Karen A Pooley, Douglas F Easton, Angela Cox, Barbara Burwinkel
Affiliations
Multicenter Study

The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study

Bernd Frank et al. Breast Cancer Res Treat. 2008 Sep.

Abstract

A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.

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