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. 1974 Sep;35(9):427-31.

Efficacy of dantrolene sodium in the treatment of spasticity

M Chipman  1 , S Kaul, M Lambie
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  • PMID: 17894068

Efficacy of dantrolene sodium in the treatment of spasticity

M Chipman et al. Dis Nerv Syst. 1974 Sep.

Abstract

Dantrolene sodium was effective in controlling spasticity and improving function in 11 of 13 patients taking part in a 14-week double-blind crossover study. Clonus and lower-extremity tendon jerks were reduced in almost all patients (10 and 11 respectively) during dantrolene sodium therapy at 200 to 400 mg/day. Activities of daily living showed marked improvement in 3 cases and moderate improvement in 8. All 13 patients reported decreases in the frequency of intermittent painful spasm. Side effects were minimal and consisted mainly of an initial 3- to 4-day period of weakness and lightheadedness.

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