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. 2007 Sep 21;2(9):589-94.
doi: 10.1021/cb7001686.

First International Meeting on Quadruplex DNA

W David Wilson  1 , Hiroshi Sugiyama
Affiliations

First International Meeting on Quadruplex DNA

W David Wilson et al. ACS Chem Biol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
The historic Brown Hotel meeting site and sidewalk clock (left). The “Thunder Over Louisville” Kentucky Derby fireworks (right), which could be seen from the Quadruplex Meeting opening reception.
Figure 1
Figure 1
The historic Brown Hotel meeting site and sidewalk clock (left). The “Thunder Over Louisville” Kentucky Derby fireworks (right), which could be seen from the Quadruplex Meeting opening reception.
Figure 2
Figure 2
a) H-bonded, four-G stacking unit of quadruplexes: in the model on the right, a K+ ion can be seen (pink) coordinated to the G carbonyl oxygens (red) that point to the center of the four-G tetramer unit that forms the core structure of G4 DNA quadruplexes. Other atoms in the model are green, C; blue, N; and white, H. b) Possible folding models for the human telomere G4 DNA structure. The G bases in the G4 units can be either anti (blue) or syn (red) as shown for a parallel (left) or propeller, a basket (center), or hybrid (right) conformation. c) Molecular model of a human telomere hybrid structure (5) with bases in green, backbone sugars and phosphate shown as a ribbon, and coordinated K+ as yellow spheres. The model is for the major human telomere conformation found in the mix of species in K+ solution (, , –9).
Figure 2
Figure 2
a) H-bonded, four-G stacking unit of quadruplexes: in the model on the right, a K+ ion can be seen (pink) coordinated to the G carbonyl oxygens (red) that point to the center of the four-G tetramer unit that forms the core structure of G4 DNA quadruplexes. Other atoms in the model are green, C; blue, N; and white, H. b) Possible folding models for the human telomere G4 DNA structure. The G bases in the G4 units can be either anti (blue) or syn (red) as shown for a parallel (left) or propeller, a basket (center), or hybrid (right) conformation. c) Molecular model of a human telomere hybrid structure (5) with bases in green, backbone sugars and phosphate shown as a ribbon, and coordinated K+ as yellow spheres. The model is for the major human telomere conformation found in the mix of species in K+ solution (, , –9).
Figure 2
Figure 2
a) H-bonded, four-G stacking unit of quadruplexes: in the model on the right, a K+ ion can be seen (pink) coordinated to the G carbonyl oxygens (red) that point to the center of the four-G tetramer unit that forms the core structure of G4 DNA quadruplexes. Other atoms in the model are green, C; blue, N; and white, H. b) Possible folding models for the human telomere G4 DNA structure. The G bases in the G4 units can be either anti (blue) or syn (red) as shown for a parallel (left) or propeller, a basket (center), or hybrid (right) conformation. c) Molecular model of a human telomere hybrid structure (5) with bases in green, backbone sugars and phosphate shown as a ribbon, and coordinated K+ as yellow spheres. The model is for the major human telomere conformation found in the mix of species in K+ solution (, , –9).
See this image and copyright information in PMC

References

    1. Sun D, Thompson B, Cathers BE, Salazar M, Kerwin SM, Trent JO, Jenkins TC, Neidle S, Hurley LH. Inhibition of human telomerase by a G-quadruplex-interactive compound. J. Med. Chem. 1997;40:2113–2116. - PubMed
    1. Phan AT, Luu KN, Patel DJ. Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution. Nucleic Acids Res. 2006;34:5715–5719. - PMC - PubMed
    1. Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ. Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold. J. Am. Chem. Soc. 2006;128:9963–9970. - PMC - PubMed
    1. Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ. Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J. Am. Chem. Soc. 2007;129:4386–4392. - PMC - PubMed
    1. Xu Y, Noguchi Y, Sugiyama H. The new models of the human telomere d[AGGG(TTAGGG)3] in K+ solution. Bioorg. Med. Chem. 2006;14:5584–5591. - PubMed

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