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Review
. 2007 Oct;92(10):902-8.
doi: 10.1136/adc.2006.110999.

Guidelines for the diagnosis and management of cow's milk protein allergy in infants

Yvan Vandenplas  1 , Sibylle Koletzko, Erika Isolauri, David Hill, Arnold P Oranje, Martin Brueton, Annamaria Staiano, Christophe Dupont
Affiliations
Review

Guidelines for the diagnosis and management of cow's milk protein allergy in infants

Yvan Vandenplas et al. Arch Dis Child. 2007 Oct.

Erratum in

  • Arch Dis Child. 2007 Oct;92(10):following 908
  • Arch Dis Child. 2008 Jan;93(1):93

Abstract

Our aim was to develop guidance for general paediatricians and primary care physicians in diagnosing and managing cow's milk protein allergy in infants. The guidelines were developed by discussion based on existing national recommendations and standards, clinical experience and, whenever possible, evidence from the literature. Separate algorithms cover breast-fed and formula-fed infants. The recommendations emphasise the importance of comprehensive history taking and careful physical examination. Patients with severe symptoms need to be referred to a specialist. Elimination of cow's milk protein from the infant's or mother's diet and challenges are the gold standard for diagnosis. This guidance is intended as a basis for local discussion, implementation and prospective evaluation. The algorithms should be regularly assessed using clinical audit standards. Once validated, the diagnostic framework could provide a standardised approach in epidemiological and therapeutic studies.

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Conflict of interest statement

Competing interests: DH, CD, MB, SK and YV declare they have received support for clinical research projects from SHS/Nutricia and the same authors and MB declare they have presented lectures at SHS/Nutricia‐sponsored meetings. Also, SK has presented lectures at sponsored meetings and received support for scientific work from Mead Johnson and Nestle. YV has received support from Janssen Pharmaceuticals, Astra, Wyeth, Biocodex and Nestle. None of the other authors made any declarations relevant to the preparation of this manuscript. The authors declare the absence of competing interests and confirm their independence regarding the content of this manuscript.

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