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Review
. 2007 Oct;92(10):909-15.
doi: 10.1136/adc.2006.111500.

Meningococcal A, C, Y and W-135 polysaccharide-protein conjugate vaccines

David Pace  1 , Andrew J Pollard
Affiliations
Review

Meningococcal A, C, Y and W-135 polysaccharide-protein conjugate vaccines

David Pace et al. Arch Dis Child. 2007 Oct.

Abstract

Serogroup C meningococcal conjugate vaccines, first launched in the UK in 1999, have been used successfully in Australia, Canada and several other European countries. Combination conjugate vaccines, containing more than one meningococcal polysaccharide, have been developed to broaden protection against the disease. A tetravalent meningococcal A, C, Y and W-135 conjugate vaccine was licensed for use in 11-55 year old adolescents and adults in the US in January 2005, and subsequently also in 2-11 year old children in Canada in May 2006. This article discusses the different glycoconjugate meningococcal vaccines which have been developed and the potential for their use to control disease caused by serogroups A, C, Y and W-135 of Neisseria meningitidis.

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Conflict of interest statement

Competing interests: DP has received travel grants from GlaxoSmithKline Vaccines to attend scientific meetings. AJP acts as chief investigator for clinical trials conducted on behalf of Oxford University and sponsored by vaccine manufacturers (Sanofi Pasteur MSD, Novartis Vaccines, GlaxoSmithKline Biologicals, Sanofi Pasteur and Wyeth Vaccines), and has directed trials of MenACYW vaccines, manufactured by Novartis Vaccines, and a Hib‐MenC vaccine, manufactured by GlaxoSmithKline Vaccines. He has received assistance from vaccine manufacturers to attend scientific meetings. Industry‐sourced consultancies and honoraria for lecturing or writing are paid directly to an independent charity or a fund held by the Department of Paediatrics, University of Oxford. He is an inventor on patents in the area of MenB vaccines.

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