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. 2007 Oct;71(10):1606-9.
doi: 10.1253/circj.71.1606.

Association of atrial arrhythmia and sinus node dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia

Naokata Sumitomo  1 , Harumizu Sakurada, Kazuo Taniguchi, Masaharu Matsumura, Osamu Abe, Michio Miyashita, Hiroshi Kanamaru, Kensuke Karasawa, Mamoru Ayusawa, Seiji Fukamizu, Iori Nagaoka, Minoru Horie, Kensuke Harada, Masayasu Hiraoka
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Free article

Association of atrial arrhythmia and sinus node dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia

Naokata Sumitomo et al. Circ J. 2007 Oct.
Free article

Abstract

Background: This study was performed to investigate the frequency and importance of supraventricular arrhythmia and sinus node (SN) dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT).

Methods and results: Eight patients with CPVT (mean age: 16.8+/-8.1 years) underwent an electrophysiological study. SN recovery time (1,389+/-394 ms) was slightly prolonged, and 4 of 8 patients had abnormal values. Atrial flutter (AF) was induced by low-rate atrial pacing in 2 patients and by isoproterenol infusion in 1 patient. Atrial fibrillation (Af) was induced by isoproterenol infusion in 2 patients. One patient presented with Af during the follow-up period, and 2 of 4 patients with AF/Af presented with increased SN recovery time.

Conclusions: Patients with CPVT frequently have associated with SN dysfunction, and inducible atrial tachyarrhythmias, which indicate that the pathogenesis of CPVT is limited not only to the ventricular myocardium, but also to broad regions of the heart, including the SN and atrial muscle.

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