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. 2007 Oct;139(2):284-8.
doi: 10.1111/j.1365-2141.2007.06779.x.

The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia

Giorgio La Nasa  1 , Roberto Littera, Franco Locatelli, Sara Lai, Francesco Alba, Giovanni Caocci, Daniela Lisini, Sonia Nesci, Adriana Vacca, Eugenia Piras, Maria Ester Bernardo, Alessandra Di Cesare-Merlone, Sandro Orrù, Carlo Carcassi
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The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia

Giorgio La Nasa et al. Br J Haematol. 2007 Oct.

Abstract

The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.

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