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Review
. 2007 Dec 7;282(49):35425-9.
doi: 10.1074/jbc.R700027200. Epub 2007 Sep 26.

Structure and mechanism of lysine-specific demethylase enzymes

Ruchi Anand  1 , Ronen Marmorstein
Affiliations
Free article
Review

Structure and mechanism of lysine-specific demethylase enzymes

Ruchi Anand et al. J Biol Chem. .
Free article

Abstract

The discovery of histone-demethylating enzymes has revealed yet another reversible histone modification mark. In this review, we describe the structural and chemical insights that we have now derived underlying the activity of these enzymes. The recent co-crystal structures of LSD1 bound to a proparylamine-derivatized histone H3 peptide and JHDM structures bound to two different methylated histone H3 peptides illustrate the steric requirements and structural basis for substrate specificity.

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