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Review
. 2007 Oct;120(5):1266-1275.
doi: 10.1097/01.prs.0000279326.84535.2d.

Mechanisms governing the effects of vacuum-assisted closure in cardiac surgery

Malin Malmsjö  1 , Richard Ingemansson, Johan Sjögren
Affiliations
Review

Mechanisms governing the effects of vacuum-assisted closure in cardiac surgery

Malin Malmsjö et al. Plast Reconstr Surg. 2007 Oct.

Abstract

: Vacuum-assisted closure has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome achieved with its use. Scientific evidence regarding the mechanisms by which vacuum-assisted closure promotes wound healing has started to emerge, although knowledge regarding the effects on heart and lung function is still limited. The organs in the mediastinum are hemodynamically crucial, and in patients with poststernotomy mediastinitis, vulnerable bypass grafts and reduced cardiac function must be taken into consideration during vacuum-assisted closure therapy. This article provides an overview of the effects of vacuum-assisted closure on heart and lung function and summarizes the current knowledge on the mechanisms by which vacuum-assisted closure therapy promotes wound healing.

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References

    1. Raudat, C. W., Pagel, J., Woodhall, D., et al. Early intervention and aggressive management of infected median sternotomy incision: A review of 2242 open-heart procedures. Am. Surg. 63: 238, 1997.
    1. El Oakley, R. M., and Wright, J. E. Postoperative mediastinitis: Classification and management. Ann. Thorac. Surg. 61: 1030, 1996.
    1. Crabtree, T. D., Codd, J. E., Fraser, V. J., et al. Multivariate analysis of risk factors for deep and superficial sternal infection after coronary artery bypass grafting at a tertiary care medical center. Semin. Thorac. Cardiovasc. Surg. 16: 53, 2004.
    1. Lu, J. C., Grayson, A. D., Jha, P., et al. Risk factors for sternal wound infection and mid-term survival following coronary artery bypass surgery. Eur. J. Cardiothorac. Surg. 23: 943, 2003.
    1. Obdeijn, M. C., de Lange, M. Y., Lichtendahl, D. H., et al. Vacuum-assisted closure in the treatment of poststernotomy mediastinitis. Ann. Thorac. Surg. 68: 2358, 1999.