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Review
. 2007;28(4-5):275-83.
doi: 10.1007/s10974-007-9118-5. Epub 2007 Sep 26.

Bridging the myoplasmic gap: recent developments in skeletal muscle excitation-contraction coupling

Roger A Bannister  1
Affiliations
Review

Bridging the myoplasmic gap: recent developments in skeletal muscle excitation-contraction coupling

Roger A Bannister. J Muscle Res Cell Motil. 2007.

Abstract

Conformational coupling between the L-type voltage-gated Ca(2+) channel (or 1,4-dihydropyridine receptor; DHPR) and the ryanodine-sensitive Ca(2+) release channel of the sarcoplasmic reticulum (RyR1) is the mechanistic basis for excitation-contraction (EC) coupling in skeletal muscle. In this article, recent findings regarding the roles of the individual cytoplasmic domains (the amino- and carboxyl-termini, cytoplasmic loops I-II, II-III, and III-IV) of the DHPR alpha(1S) subunit in bi-directional communication with RyR1 will be discussed.

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