doi: 10.1038/261026a0.
Production of yeast alcohol dehydrogenase isoenzymes by selection
- PMID: 179008
- DOI: 10.1038/261026a0
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Production of yeast alcohol dehydrogenase isoenzymes by selection
Nature.
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Abstract
Mutants of yeast alcohol dehydrogenase have been produced that protect the cell against the poisonous aldehyde acrolein by increasing the NADH-NAD ratio. The altered properties include changes both in binding constants and in cooperativity. Such mutants may be useful in exploring the nature of adaptation at the molecular level.
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