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. 1976 May 6;261(5555):26-9.
doi: 10.1038/261026a0.

Production of yeast alcohol dehydrogenase isoenzymes by selection

C Wills

Production of yeast alcohol dehydrogenase isoenzymes by selection

C Wills. Nature. .

Abstract

Mutants of yeast alcohol dehydrogenase have been produced that protect the cell against the poisonous aldehyde acrolein by increasing the NADH-NAD ratio. The altered properties include changes both in binding constants and in cooperativity. Such mutants may be useful in exploring the nature of adaptation at the molecular level.

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