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. 2007 Nov 15;17(22):6138-41.
doi: 10.1016/j.bmcl.2007.09.040. Epub 2007 Sep 14.

Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines

B Podeszwa  1 , H Niedbala, J Polanski, R Musiol, D Tabak, J Finster, K Serafin, M Milczarek, J Wietrzyk, S Boryczka, W Mol, J Jampilek, J Dohnal, D S Kalinowski, D R Richardson
Affiliations

Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines

B Podeszwa et al. Bioorg Med Chem Lett. .

Abstract

The structure-activity relationships of new quinoline based compounds were investigated. Quinoline-5,8-dione and styrylquinoline scaffolds were used for the design of potentially active compounds. The novel analogues had comparable antiproliferative activity to cisplatin when evaluated in a bioassay against the P388 leukemia cell line. However, these compounds appeared far less efficient against SK-N-MC neuroepithelioma cells. Analogues without the 5,8-dione structure but containing the 8-carboxylic acid group were also found to induce antiproliferative activity. Hydrophobicity as measured by HPLC did not correlate with antiproliferative activity.

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