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Review
. 2007 Oct;8(10):912-3.
doi: 10.1038/sj.embor.7401077.

The phosphorylation state of Drp1 determines cell fate

Arezu Jahani-Asl  1 , Ruth S Slack
Affiliations
Review

The phosphorylation state of Drp1 determines cell fate

Arezu Jahani-Asl et al. EMBO Rep. 2007 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Missing links between mitochondrial fission and apoptosis. Cyclic-AMP-dependent protein kinase (PKA) phosphorylates dynamin-related protein 1 (Drp1) and induces mitochondrial elongation and resistance to apoptosis. Calcineurin dephosphorylates Drp1, promotes mitochondrial fragmentation and cell vulnerability to apoptosis. Whether phospho-Drp1 confers protection through inhibiting mitochondrial fission or through other regulatory signalling molecules remains to be discovered.
None
Arezu Jahani-Asl
None
Ruth S. Slack
See this image and copyright information in PMC

Comment in

References

    1. Arnoult D, Rismanchi N, Grodet A, Roberts RG, Seeburg DP, Estaquier J, Sheng M, Blackstone C (2005) Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death. Curr Biol 15: 2112–2118 - PubMed
    1. Barsoum MJ et al. (2006) Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 25: 3900–3911 - PMC - PubMed
    1. Breckenridge DG, Stojanovic M, Marcellus RC, Shore GC (2003) Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J Cell Biol 160: 1115–1127 - PMC - PubMed
    1. Chan DC (2006) Mitochondria: dynamic organelles in disease, aging and development. Cell 125: 1241–1252 - PubMed
    1. Chang CR, Blackstone C (2007) Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. J Biol Chem 282: 21583–21587 - PubMed

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