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Clinical Trial
. 2007 Nov 7;13(41):5465-70.
doi: 10.3748/wjg.v13.i41.5465.

Improved survival for hepatocellular carcinoma with portal vein tumor thrombosis treated by intra-arterial chemotherapy combining etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil: a pilot study

Toru Ishikawa  1 , Michitaka Imai, Hiroteru Kamimura, Atsunori Tsuchiya, Tadayuki Togashi, Kouji Watanabe, Kei-ichi Seki, Hironobu Ohta, Toshiaki Yoshida, Tomoteru Kamimura
Affiliations
Clinical Trial

Improved survival for hepatocellular carcinoma with portal vein tumor thrombosis treated by intra-arterial chemotherapy combining etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil: a pilot study

Toru Ishikawa et al. World J Gastroenterol. .

Abstract

Aim: To investigate the poor prognosis of HCC with PVTT, we evaluated the efficacy by a new combination chemotherapy for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT).

Methods: From 2002 to 2007, a total of 10 consecutive patients with Stage IVA HCC accompanied by PVTT were studied prospectively to examine the efficacy of treatment by intra-arterial infusion of a chemotherapeutic agents consisting of etoposide, carboplatin, epirubicin and pharmacokinetic modulating chemotherapy by 5-FU and enteric-coated tegafur/uracil.

Results: The mean course of chemotherapy was 14.4 (range, 9-21) mo. One patient showed complete response (CR) with disappearance of HCC and PVTT after treatment, and the two patients showed partial response (PR), response rate (CR + PR/All cases 30%). The median survival time after the therapy was 457.2 d. The one-year survival rate was 70%. Adverse reactions were tolerable.

Conclusion: Although the prognosis of most patients with Stage IVA HCC by PVTT is poor, our combination chemotherapy may induces long-term survival and is an effective treatment and produced anti-tumor activity with tolerable adverse effects in patients for advanced Stage IVA HCC accompanied by PVTT.

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Figures

Figure 1
Figure 1
Cumulative survival of patients with hepatocellular carcinoma accompanied by PVTT who treated combination therapy.
Figure 2
Figure 2
Survival of patients with hepatocellular carcinoma accompanied by PVTT according to the response and control (Log-rank P < 0.05). CR: Complete response, PR; Partial response, NC; No change, PD; Progressive disease.
Figure 3
Figure 3
Survival of patients with hepatocellular carcinoma accompanied by PVTT according to Child-Pugh's stage (Log-rank P = 0.98).
See this image and copyright information in PMC

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