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. 2007 Nov 7;13(41):5476-80.
doi: 10.3748/wjg.v13.i41.5476.

Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?

Oge Tascilar  1 , Güldeniz Karadeniz Cakmak, Ishak Ozel Tekin, Ali-Ugur Emre, Bulent Hamdi Ucan, Oktay Irkorucu, Kemal Karakaya, Mesut Gül, Hüseyin Bülent Engin, Mustafa Comert
Affiliations

Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?

Oge Tascilar et al. World J Gastroenterol. .

Abstract

Aim: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice.

Methods: Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression.

Results: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 mon follow-up.

Conclusion: As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.

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