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. 2007 Nov 7;13(41):5476-80.
doi: 10.3748/wjg.v13.i41.5476.

Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?

Oge Tascilar  1 , Güldeniz Karadeniz Cakmak, Ishak Ozel Tekin, Ali-Ugur Emre, Bulent Hamdi Ucan, Oktay Irkorucu, Kemal Karakaya, Mesut Gül, Hüseyin Bülent Engin, Mustafa Comert
Affiliations

Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?

Oge Tascilar et al. World J Gastroenterol. .

Abstract

Aim: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice.

Methods: Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression.

Results: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 mon follow-up.

Conclusion: As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.

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References

    1. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990;247:49–56. - PubMed
    1. Fearon ER, Pierceall WE. The deleted in colorectal cancer (DCC) gene: a candidate tumour suppressor gene encoding a cell surface protein with similarity to neural cell adhesion molecules. Cancer Surv. 1995;24:3–17. - PubMed
    1. Christofori G. Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression. EMBO J. 2003;22:2318–2323. - PMC - PubMed
    1. Cavallaro U, Christofori G. Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough. Biochim Biophys Acta. 2001;1552:39–45. - PubMed
    1. Rothbard JB, Brackenbury R, Cunningham BA, Edelman GM. Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains. J Biol Chem. 1982;257:11064–11069. - PubMed

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