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Review
. 2007 Jun 29;9(2):E268-83.
doi: 10.1208/aapsj0902030.

Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts

K Sandy Pang  1 , Michael Weiss, Panos Macheras
Affiliations
Review

Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts

K Sandy Pang et al. AAPS J. .

Abstract

Three advanced models of pharmacokinetics are described. In the first class are physiologically based pharmacokinetic models based on in vitro data on transport and metabolism. The information is translated as transporter and enzyme activities and their attendant heterogeneities into liver and intestine models. Second are circulatory models based on transit time distribution and plasma concentration time curves. The third are fractal models for nonhomogeneous systems and non-Fickian processes are presented. The usefulness of these pharmacokinetic models, with examples, is compared.

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References

    1. Nestorov I. Whole-body physiologically based pharmacokinetic models. Expert Opin Drug Metab Toxicol. 2007;3:235–249. - PubMed
    1. Rowland M, Benet LZ, Graham GG. Clearance concepts in pharmacokinetics. J Pharmacokinet Biopharm. 1973;1:123–136. - PubMed
    1. Pang KS, Rowland M. Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cells binding, and the hepatocellular enzymatic activity on hepatic drug clearance. J Pharmacokinet Biopharm. 1977;5:625–653. - PubMed
    1. Pang KS, Chiba M. Metabolism: Scaling up from in vitro to organ and whole body. In: Welling PG, Balant LP, editors. Handbook of Experimental Pharmacology. Stuttgart, Germany: Springer-Verlag; 1994. pp. 101–187.
    1. Liu L, Pang KS. An integrated approach to model hepatic drug clearance. Eur J Pharm Sci. 2006;29:215–230. - PubMed

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