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. 2007 Dec;51(12):4505-7.
doi: 10.1128/AAC.00771-07. Epub 2007 Oct 1.

In Vitro susceptibility of methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus to a new antimicrobial, copper silicate

Kerry C Carson  1 , Jessica G Bartlett, Trina-Jean Tan, Thomas V Riley
Affiliations

In Vitro susceptibility of methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus to a new antimicrobial, copper silicate

Kerry C Carson et al. Antimicrob Agents Chemother. 2007 Dec.

Abstract

The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (> or =1 h) were seen at 2x MIC and 4x MIC. The frequency of mutation was <10(-9), and serial passage could not extend growth beyond 1.6x MIC.

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Figures

FIG. 1.
FIG. 1.
Time-kill curves of CS in MHB over a 4-h period with MRSA 101 (A) and S. aureus ATCC 29213 (B) and concentrations at MIC, 2× MIC, and 4× MIC. ▪, growth control; 2MIC, 2× MIC; 4MIC, 4× MIC; dashed lines, total kill. The experiments were conducted a minimum of three times and the results normalized. The standard error of each data point is shown.
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