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. 1976 May;73(5):1717-21.
doi: 10.1073/pnas.73.5.1717.

Effects of concanavalin A and a succinylated derivative on lymphocyte proliferation and cyclic nucleotide levels

J W Hadden, E M Hadden, J R Sadlik, R G Coffey

Effects of concanavalin A and a succinylated derivative on lymphocyte proliferation and cyclic nucleotide levels

J W Hadden et al. Proc Natl Acad Sci U S A. 1976 May.

Abstract

To better define cell surface-related changes involved in lymphocyte activation, we studied native concanavalin A (Con A) and succinylated concanavalin A (Suc-Con A) for their effects on proliferation and cyclic nucleotide levels of human peripheral blood lymphocytes. At optimal mitogenic concentrations, the two forms of Con A induce equivalent proliferation; however, the mitogenic activity of Con A progressively decreases above 50 mug/ml. In contrast, the mitogenic activity of Suc-Con A is not decreased even at 250 mug/ml.

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References

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