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Comment
. 2007 Oct;117(10):2756-8.
doi: 10.1172/JCI33563.

Role for HLA in susceptibility to infectious mononucleosis

Paul J Farrell  1
Affiliations
Comment

Role for HLA in susceptibility to infectious mononucleosis

Paul J Farrell. J Clin Invest. 2007 Oct.

Abstract

Factors involved in determining whether infectious mononucleosis occurs after primary EBV infection may include age, dose of virus received, and various genetic markers. A study by McAulay and colleagues reported in this issue of the JCI shows that the presence of certain HLA class I alleles correlates with the incidence and severity of infectious mononucleosis. These same HLA alleles are also risk factors for EBV-associated Hodgkin lymphoma (HL), supporting recent epidemiology that indicates that a history of infectious mononucleosis predisposes to HL. Recent studies suggest that an EBV vaccine might help to prevent infectious mononucleosis, and further development of this should now be considered.

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