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Review
. 2007 Sep;49(3):139-49.

Diagnosis and treatment of depression in Alzheimer's disease: impact on mood and cognition

Affiliations
  • PMID: 17912149
Review

Diagnosis and treatment of depression in Alzheimer's disease: impact on mood and cognition

B S Appleby et al. Panminerva Med. 2007 Sep.

Abstract

Depression, a common neuropsychiatric syndrome associated with lower quality of life (QOL), higher mortality, and higher caregiver burden, is estimated to occur in 20-50% of Alzheimer's disease (AD) patients. Recent research suggests that depression in AD (dAD) may differ from major depression phenomenologically and etiologically. Treatment options for dAD include behavioral modifications, pharmacotherapy, and electroconvulsive therapy. Successful treatment of dAD has been reported to improve patients' mood and QOL, as well as lower caregiver burden. Further research is needed in therapeutics of dAD to enhance treatment options and effectiveness.

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