doi: 10.1039/b711989e.
Epub 2007 Sep 14.
An esterase-activated magnetic resonance contrast agent
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- PMID: 17912410
- DOI: 10.1039/b711989e
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An esterase-activated magnetic resonance contrast agent
Chem Commun (Camb).
.
Abstract
A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO(3)(-)/CO(3)(2-) binding by the resulting negative charge.
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