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. 2007 Oct 30;69(18):1789-99.
doi: 10.1212/01.WNL.0000287431.88658.8b. Epub 2007 Oct 3.

Updated research nosology for HIV-associated neurocognitive disorders

A Antinori  1 , G Arendt, J T Becker, B J Brew, D A Byrd, M Cherner, D B Clifford, P Cinque, L G Epstein, K Goodkin, M Gisslen, I Grant, R K Heaton, J Joseph, K Marder, C M Marra, J C McArthur, M Nunn, R W Price, L Pulliam, K R Robertson, N Sacktor, V Valcour, V E Wojna
Affiliations

Updated research nosology for HIV-associated neurocognitive disorders

A Antinori et al. Neurology. .

Abstract

In 1991, the AIDS Task Force of the American Academy of Neurology published nomenclature and research case definitions to guide the diagnosis of neurologic manifestations of HIV-1 infection. Now, 16 years later, the National Institute of Mental Health and the National Institute of Neurological Diseases and Stroke have charged a working group to critically review the adequacy and utility of these definitional criteria and to identify aspects that require updating. This report represents a majority view, and unanimity was not reached on all points. It reviews our collective experience with HIV-associated neurocognitive disorders (HAND), particularly since the advent of highly active antiretroviral treatment, and their definitional criteria; discusses the impact of comorbidities; and suggests inclusion of the term asymptomatic neurocognitive impairment to categorize individuals with subclinical impairment. An algorithm is proposed to assist in standardized diagnostic classification of HAND.

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Conflict of interest statement

Disclosure: The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Prevalence of neurocognitive disorders by stage of HIV disease
Figure 2
Figure 2
Neuropsychological course for neurocognitive states of HIV+ (n = 534) vs HIV− subjects (n = 30)
Figure 3
Figure 3
Hawaii Aging with HIV cohort: Diagnostic transitions from baseline to year 1
Figure 4
Figure 4
Results of using different normative data sets to identify neuropsychological impairment in African American subjects
See this image and copyright information in PMC

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