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. 1976 Jun 11;192(4244):1143-5.
doi: 10.1126/science.179144.

Increased sarcoma virus RNA in cells transformed by leukemia viruses: model for leukemogenesis

P T Peebles, E M Scolnick, R S Howk

Increased sarcoma virus RNA in cells transformed by leukemia viruses: model for leukemogenesis

P T Peebles et al. Science. .

Abstract

A morphologically flat revertant of mink cells nonproductively infected with Moloney sarcoma virus exhibited contact inhibition and lacked detectable sarcoma virus RNA. Superinfection by usually nontransforming type C mammalian leukemia-causing viruses induced transformation and increased sarcoma virus RNA. The results suggest a model for leukemogenesis in animals by increasing, during replication of usually nontransforming leukemia viruses, the levels of RNA from potentially oncogenic cell or integrated virus transforming genes.

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