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. 2007 Oct 25;9(22):4619-22.
doi: 10.1021/ol702129w. Epub 2007 Oct 4.

Total synthesis of iejimalide B. An application of the Shiina macrolactonization

Dirk Schweitzer  1 , John J Kane, Daniel Strand, Peter McHenry, Martin Tenniswood, Paul Helquist
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Total synthesis of iejimalide B. An application of the Shiina macrolactonization

Dirk Schweitzer et al. Org Lett. .

Abstract

The potent anticancer compound iejimalide B (1) was prepared by a total synthesis through a strategy that features Julia olefinations, Wittig olefinations, a Carreira enantioselective alkynylation, a Heck reaction, a Marshall propargylation reaction, a Stille coupling, and a Shiina macrolactonization.

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