doi: 10.1021/ol702129w.
Epub 2007 Oct 4.
Total synthesis of iejimalide B. An application of the Shiina macrolactonization
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- PMID: 17915890
- DOI: 10.1021/ol702129w
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Total synthesis of iejimalide B. An application of the Shiina macrolactonization
Org Lett.
.
Abstract
The potent anticancer compound iejimalide B (1) was prepared by a total synthesis through a strategy that features Julia olefinations, Wittig olefinations, a Carreira enantioselective alkynylation, a Heck reaction, a Marshall propargylation reaction, a Stille coupling, and a Shiina macrolactonization.
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