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Review
. 2007;38(1-3):347-52.
doi: 10.1007/s12026-007-0006-2.

Inherited human IRAK-4 deficiency: an update

Capucine Picard  1 , Horst von Bernuth, Cheng-Lung Ku, Kun Yang, Anne Puel, Jean-Laurent Casanova
Affiliations
Review

Inherited human IRAK-4 deficiency: an update

Capucine Picard et al. Immunol Res. 2007.

Abstract

Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.

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