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Comparative Study
. 1991 Oct 16;107(2):111-7.
doi: 10.1007/BF00225514.

Changes in a photoreceptor polypeptide correlating with an early-onset retinal dystrophy in the cat

N G Holmes  1 , R Curtis
Affiliations
Comparative Study

Changes in a photoreceptor polypeptide correlating with an early-onset retinal dystrophy in the cat

N G Holmes et al. Mol Cell Biochem. .

Abstract

A preparation of rod outer segments has been used to study the polypeptides characteristic of an early-onset retinal dystrophy in cats (Rdy) by two-dimensional gel electrophoresis. Comparison of 2-D gels of rod outer segment preparations from retinas of normal and Rdy animals shows several differences. In particular, a polypeptide of Mr 51 kDa and pI 7.5 is present at increased levels in preparations from Rdy cats at 6 weeks, 9 weeks and 12.5 weeks of age but not at 3.5 weeks.

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