doi: 10.1007/BF00931012.
Transferrin is a growth factor for the bloodstream form of Trypanosoma brucei
Affiliations
- PMID: 1792224
- DOI: 10.1007/BF00931012
Item in Clipboard
Transferrin is a growth factor for the bloodstream form of Trypanosoma brucei
Parasitol Res.
1991.
Abstract
A method for the selective depletion of transferrin from bovine serum is presented. Bloodstream forms of Trypanosoma brucei cannot grow in medium containing transferrin-deficient serum, whereas reconstitution with transferrin restores normal growth. We conclude that transferrin is an essential growth factor for the mammalian stage of the parasite.
Similar articles
-
Bloodstream forms of Trypanosoma brucei require only small amounts of iron for growth.Parasitol Res. 1998;84(1):59-62. doi: 10.1007/s004360050357. Parasitol Res. 1998. PMID: 9491428
-
Trypanosoma brucei: growth differences in different mammalian sera are not due to the species-specificity of transferrin.Exp Parasitol. 2005 Mar;109(3):188-94. doi: 10.1016/j.exppara.2004.11.010. Epub 2005 Jan 7. Exp Parasitol. 2005. PMID: 15713451
-
An axenic culture system for the transformation of bloodstream forms to procyclic forms of Trypanosoma brucei brucei in vitro.Southeast Asian J Trop Med Public Health. 1993 Dec;24(4):706-11. Southeast Asian J Trop Med Public Health. 1993. PMID: 7939945
-
Both IgM and IgG anti-VSG antibodies initiate a cycle of aggregation-disaggregation of bloodstream forms of Trypanosoma brucei without damage to the parasite.Mol Biochem Parasitol. 1998 Mar 1;91(1):165-93. doi: 10.1016/s0166-6851(97)00191-6. Mol Biochem Parasitol. 1998. PMID: 9574934 Review.
-
The Trypanosomal Transferrin Receptor of Trypanosoma Brucei-A Review.Trop Med Infect Dis. 2019 Oct 1;4(4):126. doi: 10.3390/tropicalmed4040126. Trop Med Infect Dis. 2019. PMID: 31581506 Free PMC article. Review.
Cited by
-
Transferrin-binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei.J Cell Biol. 1995 Dec;131(5):1173-82. doi: 10.1083/jcb.131.5.1173. J Cell Biol. 1995. PMID: 8522581 Free PMC article.
-
AEE788 Inhibits Basal Body Assembly and Blocks DNA Replication in the African Trypanosome.Mol Pharmacol. 2017 May;91(5):482-498. doi: 10.1124/mol.116.106906. Epub 2017 Feb 28. Mol Pharmacol. 2017. PMID: 28246189 Free PMC article.
-
Immunobiology of African trypanosomes: need of alternative interventions.J Biomed Biotechnol. 2010;2010:389153. doi: 10.1155/2010/389153. Epub 2010 Feb 23. J Biomed Biotechnol. 2010. PMID: 20182644 Free PMC article.
-
Reconstitution of a surface transferrin binding complex in insect form Trypanosoma brucei.EMBO J. 1994 Jun 1;13(11):2565-73. doi: 10.1002/j.1460-2075.1994.tb06546.x. EMBO J. 1994. PMID: 8013456 Free PMC article.
-
Iron-dependent regulation of transferrin receptor expression in Trypanosoma brucei.Biochem J. 1999 Sep 15;342 Pt 3(Pt 3):691-6. Biochem J. 1999. PMID: 10477281 Free PMC article.