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Comment
. 2007 Oct 5;131(1):13-4.
doi: 10.1016/j.cell.2007.09.029.

Retrovirus silencing by an epigenetic TRIM

James Ellis  1 , Akitsu Hotta, Mojgan Rastegar
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Free article
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Retrovirus silencing by an epigenetic TRIM

James Ellis et al. Cell. .
Free article

Abstract

Embryonic cells silence transcription by retroviruses, but how do they recognize virus DNA? In this issue, Wolf and Goff (2007) report that a TRIM28 corepressor complex binds to the retrovirus primer binding site. Epigenetic silencing of retrovirus transcription is accomplished by "writing" a dimethyl mark on lysine 9 of histone H3 that is read by the heterochromatin protein HP1gamma.

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