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Comment
. 2007 Oct 5;131(1):17-9.
doi: 10.1016/j.cell.2007.09.028.

How to assemble a capsid

Wesley I Sundquist  1 , Christopher P Hill
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How to assemble a capsid

Wesley I Sundquist et al. Cell. .
Free article

Abstract

Retroviral capsids are composed of hexagonal arrays of the viral CA protein. In this issue of Cell, Ganser-Pornillos et al. (2007) provide a molecular model of the hexagonal HIV-1 CA lattice obtained from a new electron cryomicroscopic reconstruction. This study reveals the three principal stabilizing interfaces in the capsid lattice and explains how two different classes of inhibitors can block capsid assembly.

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