miRNAs play a tune
- PMID: 17923083
- DOI: 10.1016/j.cell.2007.09.031
miRNAs play a tune
Abstract
Two new studies describe functionally relevant interactions between microRNAs (miRNAs) and their targets in the immune system and the brain (Xiao et al., 2007; Karres et al., 2007). Furthermore, these studies illustrate the involvement of miRNAs in tuning the expression of target genes to physiologically relevant levels.
Comment on
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The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila.Cell. 2007 Oct 5;131(1):136-45. doi: 10.1016/j.cell.2007.09.020. Cell. 2007. PMID: 17923093
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MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb.Cell. 2007 Oct 5;131(1):146-59. doi: 10.1016/j.cell.2007.07.021. Cell. 2007. PMID: 17923094
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