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. 2007 Oct;64(10):1482-7.
doi: 10.1001/archneur.64.10.1482.

Reduced hippocampal functional connectivity in Alzheimer disease

Greg Allen  1 , Holly Barnard, Roderick McColl, Andrea L Hester, Julie A Fields, Myron F Weiner, Wendy K Ringe, Anne M Lipton, Matthew Brooker, Elizabeth McDonald, Craig D Rubin, C Munro Cullum
Affiliations

Reduced hippocampal functional connectivity in Alzheimer disease

Greg Allen et al. Arch Neurol. 2007 Oct.

Abstract

Objective: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease.

Design: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain.

Participants: Eight patients with probable Alzheimer disease and 8 healthy volunteers.

Results: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes.

Conclusion: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.

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